Coenzyme Q10 Improves Sperm Parameters, Oxidative Stress Markers and Sperm DNA Fragmentation in Infertile Patients with Idiopathic Oligoasthenozoospermia

PURPOSE Oxidative stress and sperm DNA fragmentation (SDF) are potential contributing factors for idiopathic male infertility. Coenzyme Q10 (CoQ10) have been reported to be effective in the treatment of infertility, general, owing its antioxidant properties. Thus, present study intends investigate effects CoQ10 therapy on semen parameters, oxidative markers SDF infertile men, specifically with oligoasthenozoospermia (OA). MATERIALS AND METHODS In this case-control study, sixty-five patients OA forty fertile men (control) were included. All participants underwent analysis based World Health Organization guidelines (5th edition, 2010). Patients received at dose 200 mg/d orally three months. Seminal plasma CoQ10, total capacity (TAC), reactive oxygen species (ROS), glutathione peroxidase (GPx), levels measured controls (baseline) pre- post-CoQ10 treatment. RESULTS months significantly improved concentration (p<0.05), progressive motility (p<0.01), seminal fluid (p<0.001), TAC GPx (p<0.001) OA. Further, ROS level (p<0.05) percentage reduced as compared baseline. also correlated positively (r=0.48, p=0.01) (r=0.59, p=0.003) while a negative correlation was recorded between (r=-0.54, p=0.006). CONCLUSIONS supplementation could improve reduce